NIBIB - Staff Page: Abesh Bhattacharjee

NIBIB - National Institute of Biomedical Imaging and Bioengineering

Home > Research > NIBIB Intramural Labs > Staff Page: Xiaoyuan Chen

Abesh Kumar Bhattacharjee, Ph.D.

Research Fellow
Biological Molecular Imaging Group
PET Radiochemistry Group
Building 10, Room B3 B25
Tel: 301-594-0310
Fax: 301-480-0228
E-mail: abeshb@mail.nih.gov

Photo by JudeGustafson

Research Interests

Brain Imaging

Development and in-vivo testing of PET radioligands
Brain signaling in neurodegenerative diseases (Parkinson’s, Alzheimer’s diseases)
Effects of acute and chronic administration of dopaminergic drug on brain phospholipase-A2-mediated signal transduction
Brain dopaminergic signal transduction in neuropsychiatric disorders (e.g. attention deficit hyperactivity disorder (ADHD) and amphetamine induced addiction-withdrawal)
Vascular dementia and the dementia associated sleep apnea
In vivo transgene expression

Blood Brain Barrier

Osmotic opening of the blood brain barrier
Pharmacologic manipulation of blood brain barrier opening and enhanced drug delivery into the brain

Ultrasound

Transcranial Doppler ultrasound
Cerebral blood flow
Real time ultrasound during brain and spine surgery

Education

2001, Ph.D., Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan
1992, Bachelor of Medicine and Bachelor of Surgery (MBBS), Dhaka Medical College, Dhaka, Bangladesh

Selected Publications

Kiesewetter DO, Lang L, Ma Y, Bhattacharjee AK, Gao ZG, Joshi BV, Melman A, de Castro S, Jacobson KA. Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography. Nucl Med Biol, 36(1):3-10, 2009.

Umhau JC, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, Hussein N, Bhattacharjee AK, Ma K, Esposito G, Majchrzak S, Herscovitch P, Eckelman WC, Kurdziel KA, and Salem N Jr. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res, 50(7):1259-68, 2009.

Esposito G, Giovacchini G, Liow JS, Bhattacharjee AK, Greenstein D, Schapiro M, Hallett M, Herscovitch P, Eckelman WC, Carson RE, Rapoport SI. Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET. J Nucl Med, 49(9):1414-1421, 2008.

Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI. Imaging apomorphine stimulation of brain arachidonic acid signaling viaD₂-like receptors in unanesthetized rats. Psychopharmacology (Berlin), 197(4):557-66, 2008.

Bhattacharjee AK, Chang L, Chen M, White L, Bell JM, Bazinet RP, Rapoport SI. Chronic D-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain. Int J Neuropsychopharmacol, 11(7):957-69, 2008.

Bhattacharjee AK, Meister LM, Chang L, Bazinet RP, White L, Rapoport SI. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson’s disease. Neuroimage, 37(4):1112-21, 2007.

Esposito G, Giovacchini G, Der M, Liow JS, Bhattacharjee AK, Ma K, Herscovitch P, Channing M, Eckelman WC, Hallett M, Carson RE, Rapoport SI. Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography. Neuroimage, 34(4): 1342-51, 2007.

Bazinet RP, Bhattacharjee AK, Lee HJ. Haloperidol targets brain arachidonic acid signaling. Prog Neuropsychopharmacol Biol Psychiatry, 31(1):314-5, 2007.

Morishita A, Kondoh T, Sakurai T, Ikeda M, Bhattacharjee AK, Nakajima S, Kohmura E, Yokono K, Umetani K. Quantification of distension in rat cerebral perforating arteries. NeuroReport, 17(14):1549-53, 2006.

Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI. D-amphetamine stimulates D₂ dopamine receptor mediated brain signaling involving arachidonic acid in unanesthetized rats. Journal of Cereb Blood Flow Metab, 26(11):1378-88, 2006.

Weerasinghe GR, Coon SL, Bhattacharjee AK, Harry J, Bosetti F. Regional levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age. Brain Res Bul, 69(6):614-21, 2006.

Bhattacharjee AK, Chang L, Seemann R, Lee HJ, Bazinet RP, Rapoport SI. D₂ but not D₁ dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats. Psychopharmacology (Berlin), 180(4):735-42, 2005.

Bhattacharjee AK, Ueyama T, Kondoh T, Hayashi S, Abouelfetouh A, Sakai N, Saito N, Kohmura E. In vivo transgene expression using an adenoviral tetracycline-regulated system with neuron-specific enolase promoter. Biochem Biophys Res Commun, 317(4):1144-8, 2004.

Last reviewed on: 09/30/2009

Department of Health
and Human Services

National Institutes
of Health