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Home > Research > NIBIB Intramural Labs > Staff Page: Xiaoyuan Chen > Molecular Imaging Probe Toolbox Group
BiographyDr. Chen received his Ph.D. in 2001 from Nankai University, China. He then moved to the United States where he performed his postdoctoral research at Harvard Medical School under the mentorship of Professors Amin I. Kassis and S. James Adelstein. In 2005, Dr. Chen joined Siemens Healthcare USA, Inc., as a research scientist where he helped build Siemens Molecular Imaging Biomarker Reseach (SMIBR), which is a division of Siemens Molecular Imaging under the supervison of Dr. Hartmuth C. Kolb. Dr. Chen led several projects from preclinical discovery to clinical investigation, and was promoted to a group leader in 2006, and promoted to project manager in 2008. In the summer of 2009, Dr. Chen began his work at the National institutes of Health where he is now part of the Intramural Research Program team of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Aiming to improve the understanding of the biology, early detection of diesease, monitoring therapy response, and guiding drug discovery/development, Dr. Chen’s current research focuses on the design, synthesis, and validation of novel molecular imaging probes (peptides, peptidominetics, antibodies, proteins, small molecules, and nanoparticles) for positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), optical (bioluminescence, fluorescence and Raman), contrast enhanced ultrasound, and photoacoustic imaging, as well as multimodality imaging. In particular, his research is largely focused on the molecular targets that are related to oncology and disorders of the central nervous system. Selected PublicationsBalagurumoorthy P, Chen K, Adelstein SJ, Kassis AI. Auger Electron-Induced Double-Strand Breaks Depend on DNA Topology. Radiation Research, 170(1):70-82, 2008. Singh A, Chen K, Adelstein SJ, Kassis AI. Synthesis of Coumarin-Polyamine-Based Molecular Probe for the Detection of Hydroxyl Radicals Generated by Gamma Radiation. Radiation Research, 168(2):233-242, 2007.
Chen K, Al Aowad AF, Adelstein SJ, Kassis AI. Molecular-Docking-Guided Design, Synthesis, and Biologic Evaluation of Radioiodinated Quinazolinone Prodrugs. J Med Chem, 50(4):663-673, 2007.
Yasui LS, Chen K, Wang K, Jones TP, Caldwell J, Guse D, Kassis AI. Using Hoechst 33342 to Target Radioactivity to the Cell Nucleus. Radiation Research, 167(2):167-175, 2007.
Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. In Silico Design, Synthesis, and Biologic Evaluation of Radioiodinated Quinazolinone Derivatives for Alkaline Phosphatase-Mediated Cancer Diagnosis and Therapy. Molecular Cancer Therapeutics, 5(12):3001-3013, 2006.
Balagurumoorthy P, Chen K, Adelstein SJ, Kassis AI. Mechanisms Underlying Production of Double-Strand Breaks in Plasmid DNA after Decay of 125I-Hoechst. Radiation Research, 166(2):333-344, 2006.
Wang K, Chen K, Kassis AI. Crystal structure of 2-(2’-hydroxyphenyl)-6-tributylstannyl-4-(3H)-quinazolinone and 2-(2’-hydroxyphenyl)-6-iodo-4-(3H)-quinazolinone. Crystal Research and Technology, 41(6):622-627, 2006.
Chen K, Adelstein SJ, Kassis AI. (2E)-2-(3,5-Dimethoxyphenyl)-3-(4-ethoxy-3-iodophenyl)acrylic acid. Acta Crystallographica, E61:3517-3519, 2005.
Chen K, Adelstein SJ, Kassis AI. Molecular Simulation of Ligand-Binding with DNA: Implications for 125I-Labelled Pharmaceutical Design. International Journal of Radiation Biology, 80(11-12):921-926, 2004.
Chen K, Adelstein SJ, Kassis AI,Molecular Modeling of Interactions of Iodinated Hoechst 33342 Analogs with DNA: Implications for New Radiopharmaceutical Design. Journal of Molecular Structure: THEOCHEM, 711(1-3):49-56, 2004.
PatentsKolb HC, Chen K, et al. Imaging agents useful for identifying AD pathology. Full Patent Application submitted in July 2009. Kolb HC, Chen K, et al. Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment. Full Patent Application submitted in May 2009.
Kolb HC, Walsh JC, Chen K, Gangadharmath U, Chen G, Mocharla VP, Kasi D, Scott PJH, Liang Q. Novel substrate based PET imaging agents. Full Patent Application submitted in April 2009.
Kolb HC, Chen K, Walsh JC, Liang Q. Cyclopeptides containing RGD mimetics as imaging markers for integrins. Full Patent Application submitted in April 2009.
Kolb HC, Chen K, et al. Novel imaging agents for detecting neurological dysfunction. Full Patent Publication: WO 2009/102498.
Kolb HC, Chen K, Walsh JC, Kasi D, Mocharla VP, Chen G, Liang Q, Zhao T. Cyclic azapeptides as integrin markers. Full Patent Publication: WO 2009/018175; US 2009/0074664.
Kolb HC, Chen K, Walsh JC, Gangadharmath U, Kasi D, Wang B, Duclos BA, Liang Q, Padgett HC, Karimi F. Click chemistry-derived cyclic peptidomimetics as integrin markers. Full Patent Publication: WO 2008/033557; US 2008/0213175.
Kolb HC, Chen K, Walsh JC, Liang Q, Padgett HC, Karimi F. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins. Full Patent Publication: WO 2008/033561; US 2008/0170992.
Kolb HC, Walsh JC, Yeh RM, Chen K, Gangadharmath U, Duclos BA, Mocharla VP, Karimi F, Padgett HC, Liang Q, Zhao T. Preparation of nucleoside based proliferation imaging markers. Full Patent Publication: WO 2008/109080; US 2009/0016958.
Kolb HC, Walsh JC, Kasi D, Mocharla VP, Wang B, Gangadharmath U, Duclos BA, Chen K, Zhang W, Chen G, Padgett HC, Karimi F, Scott PJH, Gao Z, Liang Q, Collier TL, Zhao T, Xia C. Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry. Full Patent Publication: WO 2008/124703.
Kolb HC, Walsh C, Chen K. Click chemistry method for synthesizing molecular imaging probes. Full Patent Publication: WO 2006/116629; US 2006/0263293.
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