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Center for Gamma-Ray Imaging
Contents
Contact Information
University of Arizona
Department of Radiology
Arizona Health Sciences Center
P.O. Box 245067
Tucson, AZ 85724
http://gamma.radiology.arizona.edu
Principal Investigator/Contact
Harrison H. Barrett, Ph.D.
Phone: 520-626-6815
Fax: 520-626-2892
barrett@radiology.arizona.edu
Administrative Contact
Nancy Preble
Program Coordinator, Sr.
Phone: 520-626-2606
Fax: 520-626-8039
npreble@radiology.arizona.edu
Grant Number
Grant No. EB002035
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Research Emphasis
The primary focus of the Center for Gamma-Ray Imaging (CGRI) is to develop new gamma-ray imaging instruments and techniques that yield substantially improved spatial and temporal resolutions. The Center makes its imagers and expertise available to a wide community of biomedical and clinical researchers through collaborative and service-oriented interactions. The collaborative research applies these new imaging tools to basic research in functional genomics, proteomics, cancer, cardiovascular disease and cognitive neuroscience, and to clinical research in tumor detection and other selected topics. There are five core research projects:
- Detector technology research and development
- Reconstruction algorithms and system modeling
- Data acquisition, signal processing, and system development
- Image-quality assessment and system optimization
- Techniques for molecular imaging
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Current Research
CGRI strives to develop detectors, systems, and techniques within a framework of mathematical rigor. Special attention is paid to the statistics of the processes involved in image formation. CGRI makes contributions to the emerging science of objective assessment of image quality (OAIQ) and is investigating techniques for hardware optimization based on OAIQ.
The Center has developed and operates four imaging systems for biomedical research:
- FastSPECT I (development precedes CGRI)—A 24-modular camera stationary SPECT system
- FastSPECT II—A 16-modular camera stationary SPECT system with true dynamic listmode acquisition, exchangeable apertures, and an under-design CT upgrade
- The Dual Modality System—A SPECT/CT instrument utilizing CGRI's CZT-based gamma camera (the SpotImager) and a commercial X-ray source and detector
- SemiSPECT—An eight-CZT camera SPECT imager with submillimeter resolution
New detector technologies and experimental imaging systems under development include:
- Clinical SpotImager—A single CZT-based, submillimeter resolution camera system for diagnostic applications in the nuclear medicine clinic
- M3R—A multi-pinhole, multi-resolution SPECT imager testbed for hardware optimization
- ModPET—A modular camera approach to positron emission tomography (PET)
- SiliSPECT—A very high resolution silicon strip detectors for low-energy (30 KeV) SPECT being developed in collaboration with Vanderbilt University
- LumiSPECT—A dual modality gamma-ray and bioluminescence instrument using lens-coupled CCDs for molecular imaging applications
- MAPMT/Monolithic Crystals—A study to determine the intrinsic image-forming capabilities of multi-anode PMTs used in combination with the most modern scintillators
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Resource Capabilities
Instruments
- Biomedical SPECT, SPECT/CT, and SPECT/bioluminescence imagers
- Handheld SpotImagers
- Autoradiography system
- Well counters
- Hardware
- Wafer prober for ASIC testing
- Infrared transmission mapper for CZT wafers
- Gamma-ray mapping system for CZT wafers
- Optical inspection systems
- FPGA prototyping system
- Surface mount assembly and rework system
- Full machine shop
- NIM electronics
Software
- Tanner L-Edit ASIC design software
- Circuit design and simulation software (MultiSim and UltiBoard)
- AutoCAD and Solidworks design environments
- Image reconstruction software
- Algorithms for image-quality assessment
Special Features
- FastSPECT I and FastSPECT II, versatile dynamic SPECT systems for imaging animals with millimeter reconstructed resolution
- SemiSPECT and the Dual Modality System, high-performance semiconductor SPECT systems with submillimeter reconstructed resolution
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References
- Barrett HH, Myers KJ. Foundations of Image Science. John Wiley and Sons, 2004.
- Small Animal SPECT Imaging, Kluwer Academic Publishers (in press). Kupinski, MA and HH Barrett (editors). Proceedings of The Workshop on Small Animal SPECT, January 2004. Hosted by the Center for Gamma-Ray Imaging.
Application Papers From 2004
- Liu Z, Stevenson GD, Barrett HH, Kastis GA, Bettan M, Furenlid LR, Wilson DW, Woolfenden JM. Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Nucl Med & Bio 2004;31:53-65.
Image Quality Papers From 2004
- Park S, Clarkson E, Kupinski MA, Barrett HH. The efficiency of the human observer detecting random signals in random backgrounds. J Opt Soc Am A (accepted, 2004).
Instrumentation Papers From 2004
- Furenlid LR, Wilson DW, Chen Y, Kim H, Pietraski PJ, Crawford MJ, Barrett HH. FastSPECT II: A second-generation high-resolution dynamic SPECT imager. IEEE Trans Nucl Sci 2004;51(3):631-635.
- Barrett HH, Liu Z. Recent advances in small-animal SPECT, with application to cardiac imaging. American Society of Nuclear Cardiology, Symposium on Molecular Cardiology; Bethesda, MD, May 3-4, 2004.
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