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MRI visualization of regional contractility and strains of a rat heart can be analyzed in vivo with cardiac tagging.

Pittsburgh NMR Center for Biomedical Research

Contents

• Contact Information
• Grant Number
• Research Emphasis
• Current Research
• Resource Capabilities
• References

Contact Information 

Grant Number

Research Emphasis

Current Research

Resource Capabilities

Instruments

• Bruker AVANCE 11.7-T/89-mm vertical bore MRI scanner
• Bruker BIOSPEC Avance 7.0-T/21-cm MRI scanner
• Bruker BIOSPEC Avance 4.7-T/40-cm MRI scanner
• 2.35-T/31-cm MRI/MRS scanner
• Bruker DRX Avance-300 spectrometer (8.9-cm bore magnet)
• Bruker DRX Avance-500 spectrometer (5.2-cm bore magnet)
• Two Bruker DRX Avance-600 spectrometer (5.2-cm vertical bore) NMR spectrometers
• Bruker Minispec spectrometer (0.47-T)

Special Features

Facilities are available for performing MRI/MRS experiments on living animals, perfused organs, and cell suspensions. The 11.7-T, 7.0-T, and 4.7-T instruments are equipped to maintain animal temperature, monitoring ECG, respiration, and blood pressure in situ.

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References

1. Kanno S, Lin Wu L-J, Lee PC, Dodd SJ, Williams M, Griffith BP, Ho C. Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging using ultrasmall superparamagnetifc iron oxide particles. Circulation 2001;104:934-938.
2. Ye Q, Yang D, Williams M, Williams DS, Pluempitiwiriyawej C, Moura JMF, Ho C. In-vivo detection of acute rat renal allograft rejection by MRI with USPIO particles. Kidney International 2002;61:1124-1135.
3. Kochanek PM, Hendrich KS, Dixon CE, Schiding JK, Williams DS, Ho C. Cerebral blood flow at one year after controlled cortical impact in rats:  assessment by magnetic resonance imaging. Journal of Neurotrauma 2002;19:1029-11037.